The DEPArray platform (Silicon Biosystem) combines imaging technologies with manipulation and recover of individual, rare cells from a heterogeneous sample. The DEPArray also offers applications at tissue level allowing digital sorting of pure cells derived from FFPE sections that can be used for high resolution molecular analyses. Parsortix (Angle) is a flexible micro-fluidic technology for the enrichment of CTC from whole blood or PBMC, also allowing isolation of CTC clusters for studies of the interaction between CTCs and microenvironment. Samples recovered from Parsortix can be used for subsequent molecular/in vitro/in vivo analyses or in association with DEPArray for isolation of pure CTC. RareCyte provides multiplexed fluorescent imaging systems, and reagents to investigate the spatial context and liquid biopsies.