Shifting Pediatric Brain Tumor Diagnostics from Solid Tissue to Liquid-biopsies Approaches SOLID-2-LIQUID
Ente Finanziatore: Associazione Bianca Garavaglia
Principal Investigator: Dott.ssa Biassoni Veronica
Co Principal Investigator: Dr, PhD De Cecco Loris
Data di inizio:
Data di fine:
Struttura Principale: Pediatria (Oncologica)
Tissue specimens are the gold standard for analyzing tumor biology but require invasive procedures and provide only a single snapshot of the tumor. Liquid biopsies, using blood, CSF, or urine, offer a non-invasive alternative to determine genomic profiles, monitor treatment response, and assess drug resistance.
Researchers at DKFZ developed a Methylation Classifier for CNS tumors using DNA methylation on tissue samples, enhancing prognosis and treatment strategies.
This approach could be adapted for liquid biopsies, allowing biological insights to be transferred from tissue to blood, CSF, or urine. This study aims to: i) Use ctDNA in plasma for tumor characterization through methylation classifiers and genomic alterations. ii) Investigate ctDNA/ctmiRNA for disease monitoring and assess urine as a potential source of biomarkers in CNS tumors
Principal Investigator Dott.ssa Biassoni Veronica
Co Principal Investigator Dr, PhD De Cecco Loris
Struttura Principale: Pediatric (Oncology)
Clinical Area, Complex Structure
Integrated Biology of Rare Tumors
Research Area, Departmental Simple Structure
Last update: 02/09/2025