Role of chromatin organization in regulating ChrXq27.3 miRNAs’ cluster expression to refine its prognostic impact in assessing risk of relapse

PI: Andrea Rizzo 

Despite advancements in treatment, the majority of Ovarian Cancer (OC) patients relapse after initial therapy, highlighting the critical need for accurate prognostic and predictive models to improve patient outcomes. 

OC patients who are classified as low risk for disease progression are those able to maintain the expression of the ChrXq27.3 miRNA’s cluster. Understanding the mechanisms underlying the aberrant downregulation of this cluster is essential for improving prognostic accuracy and treatment strategies. 

To address this, we plan to use a combination of molecular biology and bioinformatics pipelines for analyse the epigenetic and epigenomic mechanisms responsible for the transcriptional downregulation of ChrXq27.3 in OC, thereby enhancing its prognostic significance.