The Animal Welfare Body (Organismo per il benessere animale, OPBA) is the committee responsible to monitor in vivo experiments. OPBA aims to support the scientific activity of researchers by allowing them to carry out in vivo research in compliance with current legislation, according to the international standards of Good Laboratory Practice and in full compliance with the 3Rs principle: Replacement, Reduction, Refinement. The OPBA of our Institute has 5 members: the Animal Welfare Manager, one Veterinarian specialized in laboratory animals, two Scientific Members and a Biostatistician.