Descrizione:

The research carried out by the Department of Experimental Oncology in collaboration with Clinical Departments, aims to develop knowledge and insights in the following areas:

• precision prevention, which takes in consideration individuals’ differences in lifestyle, environment and biology;
• risk identification, screening and early diagnosis in healthy individuals, integrating biomic and radiomic technologies with artificial intelligence approaches;
• precision medicine for personalized patient care;
• sensitivity-resistance to therapies, v) survival and quality of life.

By institutional 'mission', each Unit of the Research Department, albeit with their own expertise and specific skills, is called to participate in joint activities of multidisciplinary and transversal oncology research within which basic research can enhance and provide the best translational research approach.
These research projects, which arise from clinical unmet needs and/or original experimental observations, are implemented in laboratories appropriately, utilizing clinical samples of patients and ad hoc pre-clinical experimental models such as homo-heterotypic cell cultures, 3D organoid-structures, in vivo models (xenografts, xenopatients, transgenic models) for the studied malignancies. The observations generated return to the clinician, with a bi-directional approach between patient and the research laboratory. This trend will allow pre-clinical research results to be transfered into current clinical practice.
The main research areas carried out in the Experimental Oncology Department include:

• Genomic-epigenetic-metabolic biomarkers of risk, diagnosis, prognosis, response prediction (Biomics);
• Molecular and translational immunology - Immunotherapy (Immunomics);
• Sensitivity - Resistance to Therapy (Pharmacomics).