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S.C. Oncologia Medica 3 - Tumori Testa-Collo > Protocolli di ricerca clinici aperti all'arruolamento

Neoadiuvante

Neoadjuvant afatinib based treatment strategies followed by surgery in squamous cell carcinoma of the head and neck: an EORTC NOCI-HNCG window study.

Phase II study of preoperative TPF chemotherapy in locally advanced resectable oral cavity squamous cell cancer in order to improve the rate of pathological complete response.

Chemioterapia di induzione seguita da radioterapia radicale + Cetuximab verso Chemio-radioterapia nel carcinoma squamoso della testa-collo localmente avanzato (SCCHN). Studio di fase III randomizzato.



Adiuvante

A randomised, double-blind, placebo-controlled, phase III study to evaluate the efficacy and safety of afatinib (BIBW 2992) as adjuvant therapy after chemo-radiotherapy in primary unresected patients with stage III, IVa, or IVb loco-regionally advanced head and neck squamous cell carcinoma.



Malattia Recidivata o Metastatica

Cetuximab and Cisplatin with or without Paclitaxel in recurrent/metastatic head and neck cancer. Study phase IIb, randomized.

Phase II study of preoperative TPF chemotherapy in locally advanced resectable oral cavity squamous cell cancer in order to improve  the rate of pathological complete response.
A randomised, double-blind, placebo-controlled, phase III study to evaluate the efficacy and safety of afatinib (BIBW 2992) as adjuvant therapy after chemo-radiotherapy in primary unresected patients with stage III, IVa, or IVb loco-regionally advanced head and neck squamous cell carcinoma.

A randomised, open-label, phase III study to evaluate the efficacy and safety of oral afatinib (BIBW 2992) versus intravenous methotrexate in patients with recurrent and/or metastatic head and neck squamous cell carcinoma who have progressed after platinum-based therapy.

Phase II multicenter randomized, double blind, placebo controlled study assessing the efficacy of buparlisib (BKM120) plus paclitaxel vs. placebo plus paclitaxel in patients with platinum pre-treated recurrent or metastatic head and neck squamous cell carcinoma.



Terapia di supporto

Studio multicentrico, randomizzato, in doppio cieco, controllato verso placebo per valutare l’attività di un integratore alimentare a base di Ginger (Zingiber officinalis) nella gestione della nausea in pazienti che ricevono trattamenti altamente emetizzanti e la terapia antiemetica standard.

A multicenter randomized open trial to evaluate the efficacy of fentanyl pectin nasal spray (FPNS) versus Physician Choice (PC) - Usual Care (UC), in reducing incidental predictable breakthrough pain (IP-BTP) at swallowing in patients with head and neck cancer undergoing radiotherapy.



Tiroide

A Randomised, Double-Blind, Placebo-Controlled, Multi-Centre Phase III Study to Assess the Efficacy and Safety of Vandetanib (CAPRELSA™) 300 mg in Patients with Papillary or Poorly Differentiated Thyroid Cancer That Is Either Locally Advanced or Metastatic Who Are Refractory or Unsuitable for Radioiodine (RAI) Therapy.

A Randomised, Double Blind Study to Compare the Complete Remission Rate Following a 5-Week Course of Selumetinib or Placebo and Single Dose Adjuvant Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer.



Ghiandole salivari

(In apertura) Phase II study of Abiraterone acetate in patients with androgen receptor expressing, castration resistant, metastatic salivary glands cancers.



Seni paranasali

Sintart 1: Multidisciplinary approach for poor prognosis sinonasal tumors: Phase II study of chemotherapy, surgery, photon and heavy ion radiotherapy integration for more effective and less toxic treatment in operable patients.

Sintart 2: Multidisciplinary approach for poor prognosis sinonasal tumors: Phase II study of chemotherapy, photon and heavy ion radiotherapy integration for more effective and less toxic treatment in inoperable patients.

S.C. Oncologia Medica 3 - Tumori testa-collo

L’obiettivo della Struttura Tumori Testa - Collo è assicurare il più appropriato percorso diagnostico, terapeutico e assistenziale, nell’ottica della multidisciplinarietà e delle più aggiornate evidenze scientifiche, alla persona affetta da una neoplasia del distretto cervico-facciale.

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Attività Clinica

La struttura segue i propri Pazienti attenendosi a linee guida diagnostiche e terapeutiche interne aggiornate periodicamente.

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Attività di Ricerca

L’attività di ricerca biologica è svolta principalmente in collaborazione con strutture di ricerca presenti in Istituto.

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Attività Didattica

La Struttura organizza periodicamente incontri clinico-scientifici multidisciplinari e di rilevanza internazionale.

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Ultimo aggiornamento: 26-07-2017 12:18:06

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